Then, you'd have to use a USB flash drive burning utility (like Rufus) to burn the ISO file onto the flash drive as a bootable drive. You'd go to the Microsoft web site and download the WMCT ISO file for your setup (Win 10 Home 64-bit English). Here's how the process would have to go with the Windows Media Creation Tool (WMCT). (Your 4TB ext HD probably has a USB connection, which also wouldn't work.) You'd need a hard drive with a SATA connection that you could wipe clean. If you're using the 4TB external hard drive as a backup drive (that is, it has files on it that you need), then that drive wouldn't work. I just now installed windows media creation tool - how does this help? As for booting from a USB (storage device as well?) I have not tried this. Direct play is checked under 'Legacy components' of Turn Windows components on or off. I do have a large 4tereabyte external storage device.
